Division of Biology and Medicine
Center on the Biology of Aging

Faculty

Faculty

  • Karthikeyani Chellappa, PhD

    Karthikeyani Chellappa, PhD

    Assistant Professor, Department of Molecular Microbiology and Immunology

    Research interests: Aging,  Resilience, Frailty, Metabolism, Metabolic flux analysis, Systems Biology, Microbial Metabolism, Host-microbiome interactions, Transport of small molecules

  • Qian Chen

    Qian Chen, PhD

    Professor, Department of Orthopaedics

    Research Interests:  Skeletal development and aging, osteoarthritis, role of senescent cells in skeletal aging, mechano-transduction

    We study molecular mechanisms of cell aging and senescence that lead to skeletal system degenerative diseases in humans. Specifically, we use the osteoarthritic joint cartilage as our model system to analyze how senescence-associated cell transitions and interactions result in tissue pathology.

  • Robbert Creton, PhD

    Robbert Creton, PhD

    Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research interests: Alzheimer’s disease, Calcineurin signaling, High-throughput imaging, Automated analysis of behavior, Discovery of novel therapeutics.

  • Michelle Dawson

    Michelle Dawson, PhD

    Assistant Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Mechanobiology, extra-cellular matrix dynamics, senescence-associated exosomes, TGF-B signaling, fibrosis

    We study mechanisms by which senescent cells alter tissue microenvironments to promote cancer and age-related disease. We are investigating the physical and molecula alterations in senescent cells that contribute to extracellular matrix remodeling, tissue stiffening, and fibrosis.

  • Sarah Delaney

    Sarah Delaney, PhD

    Research Interests: Biological consequences of DNA damage, oxidative stress, role of chromatin structure in DNA damage repair

    We are working to establish a chemically-logical roadmap to understand how DNA base damage relates to genetic change and disease. We have developed techniques to define how chromatin influences DNA repair and circumstances in which base damage evades repair leading to mutations.

  • Patrycja Dubielecka

    Patrycja Dubielecka-Szczerba, PhD

    Associate Professor, Department of Medicine

    Research Interests: Bone marrow microenvironment, hematopoietic stem cells, effects of aging on hematopoiesis, inflammaging.

    We study age-related changes in the hematopoietic system and how the output of hematopoietic stem cells changes with age. We focus on the mechanisms of inflammatory signaling and the homeostasis of hematopoietic stem cells in the aging bone marrow microenvironment.

  • Justin Fallon

    Justin Fallon, PhD

    Research Interests:  Neuromuscular junction, adult neurogenesis and neurodegeneration, aging, Alzheimer’s Disease therapeutics

    My laboratory studies the molecular mechanisms of synapse stability and stem cell quiescence. We are also developing therapeutics to promote adult hippocampal neurogenesis in Alzheimer's Disease and other neurodegenerative disorders.

  • Nicolas Fawzi

    Nicolas Fawzi, PhD

    Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Nuclear magnetic resonance, neurodegenerative disease, RNA binding proteins, protein aggregation, phase separation. 

    My research investigates structure/function relationships of protein aggregation and phase-separated membrane-less organelles in neurodegenerative diseases of aging. I use and develop molecular simulations and solution NMR to visualize protein aggregates with atomistic resolution.

  • Richard Freiman

    Richard Freiman, PhD

    Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Reproductive aging, senescence, chromatin and transcriptional control, systemic effects of reproductive failure

    My lab's research focuses on understanding mechanisms of reproductive senescence. We investigate transcriptional programs that ensure proper reproductive aging, how deregulation leads to premature reproductive failure, and how this in turn affects systemic aging and age-related diseases.

  • Anne Hart

    Anne Hart, PhD

    Professor, Department of Neuroscience

    Research Interets: Sensory signaling, sleep and fatigue, aging and neurodegenerative diseases, Amyotrophic Lateral Sclerosis

    My research focuses on understanding basic mechanisms using the invertebrate nematode C. elegans. We study molecular and cellular sensory systems in stress and sleep, and the pathology of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS).

  • Stephen Helfand

    Stephen Helfand, MD

    Associate Director for Research, Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Genetic control of longevity, calorie restriction, sirtuins, insulin/IGF signaling

    We study the molecular mechanisms that underly aging, longevity and neurodegeneration. We are exploiting Drosophila as a model system, and more recently mice, and we use genetic approaches to study diet restriction, sirtuins and the role of chromatin homeostasis in maintaining youthfulness.

  • Yu-Wen Alvin Huang

    Yu-Wen Alvin Huang, PhD

    Assistant Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Brain aging and neurodegeneration, pluripotent stem cells, direct transdifferentiation, Alzheimer's Disease.

    The goal for my laboratory is to understand the molecular and cellular fundamentals of brain aging and neurodegeneration. We employ neural cell culture models that exploit pluripotent stem cells as well as direct trans-differentiation of somatic cells to study Alzheimer's Disease.

  • Gerwald Jogl, PhD

    Gerwald Jogl, PhD

    Associate Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Retrotransposable elements, translation, structural biology, enzymology, liquid-liquid phase separation.

     

  • Karla Kaun

    Karla Kaun, PhD

    Associate Professor, Department of Neuroscience

    Research Interests: Synaptic networks of reward and addiction, JAK-STAT signaling, cognitive decline, effects of aging on substance abuse.

    I use the fruit fly to investigate the neural substrates of drug reward at the molecular and cellular level. I investigate the neural circuitry and associated molecular mechanisms within the fly brain that regulate this memory, and how these processes change with aging.

  • Gideon Koren

    Gideon Koren, MD

    Professor, Department of Medicine

    Research Interests: Cardiovascular aging, arrhythmia, sudden cardiac death, role of senescent cells in heart aging, senolytic therapy 

    We study the mechanisms through which cell senescence leads to ventricular arrhythmias in aged hearts. Specifically, we are investigating the healing of the infarcted aged heart, both in a rabbit model and humans, and how persistent myofibroblast senescence in the scar leads to cardiac arrhythmias.

  • Jill Kreiling

    Jill Kreiling, PhD

    Associate Director for Program Development and Diversity; Associate Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Cellular senescence, chromatin changes with aging, miRNAs, neural stem cells, epigenetics

    My research investigates the role of non-coding sequences in age-associated cellular decline. We study how changes in chromatin structure in heterochromatic regions of the genome lead to dysregulation of these sequences, ultimately influencing a wide range of cellular processes.

  • Erica Larschan

    Erica Larschan, PhD

    Associate Professor of Biology, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Regulation of chromatin states and transcription, epigenetic regulation of sex-specific differences during aging.

    We study mechanisms by which genes are coordinately regulated, how these processes are affected by sex, and change during aging. Specifically, we are interested in how epigenetic chromatin changes between males and females drive sex-specific differences.

  • Jonghwan Lee

    Jonghwan Lee, PhD

    Assistant Professor, Department of Engineering

    Research Interests: Alzheimer's Disease, vascular factors, microscopic imaging, microvasculature, microcirculation.

    I am developing optical technologies for label-free imaging and genetics-free modulation of the central nervous system, both at the micrometer scale. We are implementing clinical applications, such as the mapping of brain microvascular changes in Alzheimer's Disease.

  • Eric Morrow

    Eric Morrow, PhD

    Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Brain development, maintenance, Mendelian neurodegenerative diseases, dysfuntion of endolysosomal system in aging.

    I work on mechanisms that regulate brain development and maintenance,using functional analysis of mutations that lead to neurodegeneration (autism, Christianson syndrome). We are interested in the dysfunction of the endolysosomal system, a feature in many neurodegenerative disorders.

  • Nicola Neretti

    Nicola Neretti, PhD

    Associate Director; Associate Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Computational biology, bioinformatics, chromatin, nuclear organization, cellular senescence, aging

    We study transcriptional and epigenomic changes in aging and cellular senescence. We are using single cell spatial multiomics to understand how the nuclear reorganization of the genomic architecture affects the transcriptional and translational state of cells during aging.

  • Kate O’Connor-Giles

    Kate O’Connor-Giles, PhD

    Associate Professor, Department of Neuroscience

    Research Interests: Neuronal development, neurogenetics, synaptic communication and plasticity, synaptic maintenance with aging.

    We employ a genetic approach in Drosophila to understand synapse formation, function, plasticity and aging. We focus on developing new genome engineering approaches to overcome technical challenges to study function and decline of the nervous system in vivo.

  • David Rand

    David Rand, PhD

    Professor, Department of Ecology, Evolution, and Organismal Biology

    Research Interests: Nuclear-mitochondrial genetic interactions, mitochondrial genetics of aging, molecular evolution, oxidative respiration

    We are interested in understanding how natural selection acts on genes and genomes. A major focus of the lab is to study the mitochondrial genome and its interactions with the nuclear genome, and how this interaction influences animal performance, evolutionary fitness, and aging.

  • Robert A. Reenan

    Robert A. Reenan, PhD

    Professor of Biology, Department of Molecular Biology, Cell Biology and Biochemistry

    Evolution of brain function and behavior, neurodegeneration, RNA editing, ncRNAs, chromatin, Parkinson's disease

    Dr. Reenan is an international leader in the area of eukaryotic gene regulation, and his laboratory has played a seminal role in understanding the process of RNA editing. His multidisciplinary approaches have spanned cutting-edge genetics and molecular biology, comparative genomics, computer modeling, and biophysical techniques in order to bring to light the biological importance of ancient and conserved regulatory processes. The Reenan lab's work has been funded by NIH, NSF, Ellison Medical Research Foundation, the CART fund for Alzheimer's Research, and the Cambridge Templeton Consortium's Emergence of Biological Complexity program. In the past few years Dr. Reenan has published research in journals such as Science, Nature, Cell, Neuron, and Nature Structural and Molecular Biology, as well as being highlighted in several of these journals in mini-reviews or "editor's choice" articles. Dr. Reenan's work was one of twelve groups highlighted in the FY2005 Budgetary Request to Congress by NIH-NIGMS.

  • John Sedivy

    John Sedivy, PhD

    Director; Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Chromatin homeostasis, cell senescence, retrotransposable elements, interferon, neurodegenerative disease therapy.

    We study mechanisms that lead to cell senescence, the epigenetic changes that occur in senescent cells, and the consequences of their accumulation in aging tissues. We discovered that retro transposons are activated in senescence and are exploring their inhibition as therapy for age-related diseases.

  • Carlos Giovanni (Gio) Silva-García

    Carlos Giovanni (Gio) Silva-García, PhD

    Assistant Professor, Department of Molecular Biology, Cell Biology and Biochemistry
  • Marc Tatar

    Marc Tatar, PhD

    Professor, Department of Ecology, Evolution and Organismal Biology

    Research Interests: Demography, evolution and genetics of aging, endocrine control of longevity, insulin/IGF signaling, innate immunity

    We study aging in Drosophila focusing on the function and outcomes of altered insulin/IGF signaling. We are mapping how domains of the receptor differentially control metabolic pathways impacting lifespan that are common with nutrient sensing and dietary interventions applicable to humans.

  • Marty Taylor

    Martin Taylor

    Assistant Professor of Pathology and Laboratory Medicine

    Research Interests: Human LINE-1 Transposon, "Dark genome", Biochemistry, Structural Biology, Enzymology and  Mechanisms, Drug and biological therapy development, Cytosolic nucleic acids and innate immunity, Senescence, Cancer biology

    We study the human LINE-1 transposon, an ancient DNA parasite that has written ~1/3 of the human genome and is increasingly recognized to contribute to the pathologies of cancer, autoimmunity, neurodegeneration, and other diseases of aging. We use approaches spanning structural biology and biochemistry to drug and therapeutic development, mouse modeling, and clinical trials to understand how LINE-1 works, how and how much it contributes to disease, and to develop new diagnostics and therapeutics.

  • Gregorio Valdez

    Gregorio Valdez, PhD

    Associate Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Synaptic aging, neuromuscular junction, motor neuron–glial cell interaction, Alzheimer’s Disease. 

    My research uses the neuromuscular junction as a model synapse. We are focused on discovering pathways and factors that function to preserve and restore the function
    of the nervous system and skeletal muscles during normal aging and in age-related diseases.

  • Ashley Webb

    Ashley Webb, PhD

    Adjunct Associate Professor, Department of Molecular Biology, Cell Biology and Biochemistry

    Research Interests: Epigenetic mechanisms of brain aging, neurodegeneration, neural stem cells, FOXO transcription factors.

    My research is aimed at understanding the molecular mechanisms of brain aging and neurodegeneration. In particular, we study how transcriptional and epigenetic networks preserve healthy neurogenesis and neuronal function, and how these networks are perturbed with age.

  • Anatoly Zhitkovich

    Anatoly Zhitkovich, PhD

    Professor, Department of Pathology and Laboratory Medicine

    Research Interests: DNA damage, DNA repair, replication stress, chromatin changes, proteotoxic stress.

    My research is focused on the determination of chemical and biochemical mechanisms of DNA damage and mutagenesis by environmental stressors. We study how proteotoxic and hypoxia-like conditions impact chromatin structure, formation and repair of DNA damage.