Research interests: Aging,  Resilience, Frailty, Metabolism, Metabolic flux analysis, Systems Biology, Microbial Metabolism, Host-microbiome interactions, Transport of small molecules

Research Interests:  Skeletal development and aging, osteoarthritis, role of senescent cells in skeletal aging, mechano-transduction

We study molecular mechanisms of cell aging and senescence that lead to skeletal system degenerative diseases in humans. Specifically, we use the osteoarthritic joint cartilage as our model system to analyze how senescence-associated cell transitions and interactions result in tissue pathology.

Research interests: Alzheimer’s disease, Calcineurin signaling, High-throughput imaging, Automated analysis of behavior, Discovery of novel therapeutics.

Research Interests: Mechanobiology, extra-cellular matrix dynamics, senescence-associated exosomes, TGF-B signaling, fibrosis

We study mechanisms by which senescent cells alter tissue microenvironments to promote cancer and age-related disease. We are investigating the physical and molecula alterations in senescent cells that contribute to extracellular matrix remodeling, tissue stiffening, and fibrosis.

Research Interests: Biological consequences of DNA damage, oxidative stress, role of chromatin structure in DNA damage repair

We are working to establish a chemically-logical roadmap to understand how DNA base damage relates to genetic change and disease. We have developed techniques to define how chromatin influences DNA repair and circumstances in which base damage evades repair leading to mutations.

Research Interests: Bone marrow microenvironment, hematopoietic stem cells, effects of aging on hematopoiesis, inflammaging.

We study age-related changes in the hematopoietic system and how the output of hematopoietic stem cells changes with age. We focus on the mechanisms of inflammatory signaling and the homeostasis of hematopoietic stem cells in the aging bone marrow microenvironment.

Research Interests:  Neuromuscular junction, adult neurogenesis and neurodegeneration, aging, Alzheimer’s Disease therapeutics

My laboratory studies the molecular mechanisms of synapse stability and stem cell quiescence. We are also developing therapeutics to promote adult hippocampal neurogenesis in Alzheimer's Disease and other neurodegenerative disorders.

Research Interests: Nuclear magnetic resonance, neurodegenerative disease, RNA binding proteins, protein aggregation, phase separation. 

My research investigates structure/function relationships of protein aggregation and phase-separated membrane-less organelles in neurodegenerative diseases of aging. I use and develop molecular simulations and solution NMR to visualize protein aggregates with atomistic resolution.

Research Interests: Reproductive aging, senescence, chromatin and transcriptional control, systemic effects of reproductive failure

My lab's research focuses on understanding mechanisms of reproductive senescence. We investigate transcriptional programs that ensure proper reproductive aging, how deregulation leads to premature reproductive failure, and how this in turn affects systemic aging and age-related diseases.

Research Interets: Sensory signaling, sleep and fatigue, aging and neurodegenerative diseases, Amyotrophic Lateral Sclerosis

My research focuses on understanding basic mechanisms using the invertebrate nematode C. elegans. We study molecular and cellular sensory systems in stress and sleep, and the pathology of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS).

Research Interests: Genetic control of longevity, calorie restriction, sirtuins, insulin/IGF signaling

We study the molecular mechanisms that underly aging, longevity and neurodegeneration. We are exploiting Drosophila as a model system, and more recently mice, and we use genetic approaches to study diet restriction, sirtuins and the role of chromatin homeostasis in maintaining youthfulness.

Research Interests: Brain aging and neurodegeneration, pluripotent stem cells, direct transdifferentiation, Alzheimer's Disease.

The goal for my laboratory is to understand the molecular and cellular fundamentals of brain aging and neurodegeneration. We employ neural cell culture models that exploit pluripotent stem cells as well as direct trans-differentiation of somatic cells to study Alzheimer's Disease.

Research Interests: Retrotransposable elements, translation, structural biology, enzymology, liquid-liquid phase separation.

Research Interests: Synaptic networks of reward and addiction, JAK-STAT signaling, cognitive decline, effects of aging on substance abuse.

I use the fruit fly to investigate the neural substrates of drug reward at the molecular and cellular level. I investigate the neural circuitry and associated molecular mechanisms within the fly brain that regulate this memory, and how these processes change with aging.

Research Interests: Cardiovascular aging, arrhythmia, sudden cardiac death, role of senescent cells in heart aging, senolytic therapy 

We study the mechanisms through which cell senescence leads to ventricular arrhythmias in aged hearts. Specifically, we are investigating the healing of the infarcted aged heart, both in a rabbit model and humans, and how persistent myofibroblast senescence in the scar leads to cardiac arrhythmias.

Research Interests: Cellular senescence, chromatin changes with aging, miRNAs, neural stem cells, epigenetics

My research investigates the role of non-coding sequences in age-associated cellular decline. We study how changes in chromatin structure in heterochromatic regions of the genome lead to dysregulation of these sequences, ultimately influencing a wide range of cellular processes.

Research Interests: Regulation of chromatin states and transcription, epigenetic regulation of sex-specific differences during aging.

We study mechanisms by which genes are coordinately regulated, how these processes are affected by sex, and change during aging. Specifically, we are interested in how epigenetic chromatin changes between males and females drive sex-specific differences.

Research Interests: Alzheimer's Disease, vascular factors, microscopic imaging, microvasculature, microcirculation.

I am developing optical technologies for label-free imaging and genetics-free modulation of the central nervous system, both at the micrometer scale. We are implementing clinical applications, such as the mapping of brain microvascular changes in Alzheimer's Disease.

Research Interests: Brain development, maintenance, Mendelian neurodegenerative diseases, dysfuntion of endolysosomal system in aging.

I work on mechanisms that regulate brain development and maintenance,using functional analysis of mutations that lead to neurodegeneration (autism, Christianson syndrome). We are interested in the dysfunction of the endolysosomal system, a feature in many neurodegenerative disorders.

Research Interests: Computational biology, bioinformatics, chromatin, nuclear organization, cellular senescence, aging

We study transcriptional and epigenomic changes in aging and cellular senescence. We are using single cell spatial multiomics to understand how the nuclear reorganization of the genomic architecture affects the transcriptional and translational state of cells during aging.

Research Interests: Neuronal development, neurogenetics, synaptic communication and plasticity, synaptic maintenance with aging.

We employ a genetic approach in Drosophila to understand synapse formation, function, plasticity and aging. We focus on developing new genome engineering approaches to overcome technical challenges to study function and decline of the nervous system in vivo.

Research Interests: Nuclear-mitochondrial genetic interactions, mitochondrial genetics of aging, molecular evolution, oxidative respiration

We are interested in understanding how natural selection acts on genes and genomes. A major focus of the lab is to study the mitochondrial genome and its interactions with the nuclear genome, and how this interaction influences animal performance, evolutionary fitness, and aging.

Evolution of brain function and behavior, neurodegeneration, RNA editing, ncRNAs, chromatin, Parkinson's disease

Dr. Reenan is an international leader in the area of eukaryotic gene regulation, and his laboratory has played a seminal role in understanding the process of RNA editing. His multidisciplinary approaches have spanned cutting-edge genetics and molecular biology, comparative genomics, computer modeling, and biophysical techniques in order to bring to light the biological importance of ancient and conserved regulatory processes. The Reenan lab's work has been funded by NIH, NSF, Ellison Medical Research Foundation, the CART fund for Alzheimer's Research, and the Cambridge Templeton Consortium's Emergence of Biological Complexity program. In the past few years Dr. Reenan has published research in journals such as Science, Nature, Cell, Neuron, and Nature Structural and Molecular Biology, as well as being highlighted in several of these journals in mini-reviews or "editor's choice" articles. Dr. Reenan's work was one of twelve groups highlighted in the FY2005 Budgetary Request to Congress by NIH-NIGMS.

Research Interests: Chromatin homeostasis, cell senescence, retrotransposable elements, interferon, neurodegenerative disease therapy.

We study mechanisms that lead to cell senescence, the epigenetic changes that occur in senescent cells, and the consequences of their accumulation in aging tissues. We discovered that retro transposons are activated in senescence and are exploring their inhibition as therapy for age-related diseases.

Research Interests: Demography, evolution and genetics of aging, endocrine control of longevity, insulin/IGF signaling, innate immunity

We study aging in Drosophila focusing on the function and outcomes of altered insulin/IGF signaling. We are mapping how domains of the receptor differentially control metabolic pathways impacting lifespan that are common with nutrient sensing and dietary interventions applicable to humans.

Research Interests: Human LINE-1 Transposon, "Dark genome", Biochemistry, Structural Biology, Enzymology and  Mechanisms, Drug and biological therapy development, Cytosolic nucleic acids and innate immunity, Senescence, Cancer biology

We study the human LINE-1 transposon, an ancient DNA parasite that has written ~1/3 of the human genome and is increasingly recognized to contribute to the pathologies of cancer, autoimmunity, neurodegeneration, and other diseases of aging. We use approaches spanning structural biology and biochemistry to drug and therapeutic development, mouse modeling, and clinical trials to understand how LINE-1 works, how and how much it contributes to disease, and to develop new diagnostics and therapeutics.

Research Interests: Synaptic aging, neuromuscular junction, motor neuron–glial cell interaction, Alzheimer’s Disease. 

My research uses the neuromuscular junction as a model synapse. We are focused on discovering pathways and factors that function to preserve and restore the function
of the nervous system and skeletal muscles during normal aging and in age-related diseases.

Research Interests: Epigenetic mechanisms of brain aging, neurodegeneration, neural stem cells, FOXO transcription factors.

My research is aimed at understanding the molecular mechanisms of brain aging and neurodegeneration. In particular, we study how transcriptional and epigenetic networks preserve healthy neurogenesis and neuronal function, and how these networks are perturbed with age.

Research Interests: DNA damage, DNA repair, replication stress, chromatin changes, proteotoxic stress.

My research is focused on the determination of chemical and biochemical mechanisms of DNA damage and mutagenesis by environmental stressors. We study how proteotoxic and hypoxia-like conditions impact chromatin structure, formation and repair of DNA damage.