Computational biology, bioinformatics, gene networks, and chromatin.
Dr. Kreiling’s research is focused on understanding the connection between age-associated changes in the epigenetic signature of chromatin and the resulting changes in gene expression. Aging is the primary risk factor for the onset of multiple degenerative conditions, such as dementias, cardiovascular diseases, diabetes and cancer, that are responsible for considerable morbidity and mortality. Many of these disorders result from, at least in part, epigenetic changes and the accumulation of DNA damage that lead to genome instability over time. Ultimately, understanding the mechanisms in which age-associated changes in chromatin structure result in the development of aging phenotypes may lead to therapeutic interventions that extend both healthspan and lifespan.