Center on the Biology of Aging

Research Interests: Cardiovascular aging, arrhythmia, sudden cardiac death, role of senescent cells in heart aging, senolytic therapy 

We study the mechanisms through which cell senescence leads to ventricular arrhythmias in aged hearts. Specifically, we are investigating the healing of the infarcted aged heart, both in a rabbit model and humans, and how persistent myofibroblast senescence in the scar leads to cardiac arrhythmias.