Center on the Biology of Aging

Graduated: December 2020
Current Location:  In Vivo Antibody Discovery, Worcester, MA

Mentor: John M. Sedivy

Description of trainee's research project and progress: Anna Petrashen was a student in the lab of Professor John Sedivy. Her project investigated the manner in which MYC regulates IGF-1 signaling in the mouse. Anna matriculated in the MCB Program in September 2014. She was supported for two years by this T32 (09/01/15-08/31/17). She successfully defended her Ph.D. on December 9, 2019 (time to Ph.D. defense, 5.3 years). She contributed to the publication of four papers while at Brown. One more paper is in preparation. She is currently pursuing postdoctoral studies at Brown University with Dr. John Sedivy.

Publications:
1) Helou YA, Petrashen AP, Salomon AR (2015). Vav1 regulates T-Cell activation through a feedback mechanism and crosstalk between the T-Cell Receptor and CD28. J Proteome Res 14: 2963–2975.

2) Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, LapierreLR (2016). Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Autophagy 12: 261-272.

Conference presentations: Anna has presented at two national conferences and two local meetings in addition to yearly participation in program retreats and data clubs at Brown University.

•      Petrashen AP, Sedivy JM. Translational regulation of insulin-like growth factor 1 by MYC. Cold Spring Harbor Laboratory Mechanisms of Aging Meeting, Cold Spring Harbor, NY, September 26-30, 2016, (abstract-poster).

•      Petrashen AP, Zhao X, Sedivy JM. The MYC-ing link: Convergence of pro-longevity pathways under one regulator.  Providence Area Aging Research Foundation, Brown University, Providence, RI, October 25, 2016 (talk).

•      Petrashen AP, Sedivy JM. Translational regulation of insulin-like growth factor 1 by MYC. Second Annual Glenn Symposium on Aging, Yale University, New Haven, CT, November 4, 2016 (short talk selected from abstracts).

•      Petrashen AP, Sedivy JM. Tissue-specific translational regulation of insulin-like growth factor 1 by MYC. Gordon Conference on IGF & Insulin System in Physiology and Disease, Ventura Beach Marriott, Ventura, CA, March 12, 2017 (short talk selected from abstracts).