Center on the Biology of Aging

Graduated:  August 2017
Current location: Harvard University, Cambridge, MA

Mentor: Erica N. Larschan

Description of trainee's research project and progress: Emily G. Kaye was a student in the lab of Assistant Professor Erica Larschan. Emily's project examined how a chromatin mark involved in aging, H4K16Ac, is precisely targeted to specific regions of the genome. Emily matriculated at Brown in September 2012. She was supported for two years by this T32 (09/01/13-08/31/15). She successfully defended her Ph.D. on July 21, 2017 (time to Ph.D. defense, 4.9 years). She contributed to the publication of three papers while at Brown. She is currently pursuing postdoctoral studies at Harvard Medical School with Dr. Karen Adelman.

Publications:
1) Kuzu G*, Kaye EG*, Chery J, Siggers T, Yang L, Dobson J, Boor S, Bliss J, Liu W, Jogl G, Rohs R, Singh N, BulykM, Tolstorukov M, Larschan EN. Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation. PLoS Genetics, 2016. (*co-first authors). http://dx.doi.org/10.1371/journal.pgen.1006120

Conference presentations:
1) Kaye EG, Kuzu G, Kurland JV, Bulyk ML, Tolstorukov MY, Larschan EN. Competition between the essential transcription factors GAF and CLAMP defines their binding patterns in Drosophila melanogaster. 34th Summer Symposium in Molecular Biology: Chromatin and Epigenetic Regulation of Transcription, Penn State University, State College, PA, July 21-24, 2015, (Abstract-poster).

2) Kaye, EG, Kuzu, G, Kurland, JV, Bulyk, ML, Tolstorukov, MY, Larschan, EN. Understanding GA-repeat targeting by the essential Drosophila transcription factors GAF and CLAMP. All About Polycomb Meeting, Boston, MA, October 15, 2015, (Abstract-poster).

3) Kaye EG, Kuzu G, Kurland JV, Wolle D, Kubidaeva A, Schedl P, Bulyk ML, Tolstorukov MY, Larschan EN. Competition between two essential transcription factors regulates dosage compensation in D. melanogaster. Cold Spring Harbor Laboratory Conference Nuclear Organization and Function, Cold Spring Harbor, NY, May 3-7, 2016, (Abstract-talk).

Honors: Best poster award, MCB Graduate Program retreat, 2015.